The Walking Dead: The Ones Who Live trailer hints that Rick Grimes may lose his hand in the upcoming show. The trailer shows a brief moment where a hook is seen gripping the end of Rick's weapon, indicating the loss of his hand. This development will be a recent event, as Rick had both hands in his cameo in the series finale. In the comics, Rick also loses his hand during the Woodbury arc, but the show decided to keep his hand intact due to the challenges it would pose for action scenes. 

However, the loss of his hand in the upcoming show can lead to a character-driven storyline that explores Rick's adjustment to this change. It's possible that losing his hand will be a punishment for trying to break away from the evil organization, the Civic Republic Military, and will serve as a constant reminder of the risks involved. The Walking Dead: The Ones Who Live premieres on February 25.